Three decades of Wnt signalling

نویسندگان

چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Wnt signalling: Antagonistic Dickkopfs

Dickkopf proteins are secreted antagonists of the Wnt cell signalling molecules, which have a novel mode of action. Dickkopf1 binds to the LRP5/6 Wnt co-receptor and prevents the formation of active Wnt--Frizzled--LRP5/6 receptor complexes, thus blocking the canonical Wnt--beta-catenin pathway.

متن کامل

Three Decades of Multiprocessors

During the last 25 years, the author has never reallv considered any alternative to the multiprocessor (mP) for general-purpose, cost-effective, nonminimal come -rs. This involvement with mPs at Digital Equipment Corporation (DEC), Carnegie Mellon University (CMU), Encore, Stardent, and Kendall Square Research (KSR) included 16 computers. Fourteen were built, including 7 for research or advance...

متن کامل

Three Decades of Continuous Records for Biophysical Chemistry Laboratory (BCL)

The Biophysical Chemistry Laboratory (BCL) was established in 1986 at Institute of Biochemistry and Biophysics (IBB), University of Tehran as the main base and the mother of biophysical chemistry in Iran. BCL is a famous worldwide research lab in the area of thermodynamics of protein denaturation and biomacromolecular interaction. The first student that joined BCL was MSc student in 1987, while...

متن کامل

Drugging Wnt signalling in cancer.

Aberrant regulation of the Wnt signalling pathway has emerged as a prevalent theme in cancer biology. This chapter summarizes the research that provides a proof of concept for inhibiting Wnt signalling in cancer, the potential means by which this could be achieved, and some recent advances towards this goal. A brief discussion of molecular diagnostics and possible safety concerns is also provided.

متن کامل

Mitotic and mitogenic Wnt signalling.

Canonical Wnt signalling plays an important role in development, tissue homeostasis, and cancer. At the cellular level, canonical Wnt signalling acts by regulating cell fate, cell growth, and cell proliferation. With regard to proliferation, there is increasing evidence for a complex interaction between canonical Wnt signalling and the cell cycle. Mitogenic Wnt signalling regulates cell prolife...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: The EMBO Journal

سال: 2012

ISSN: 0261-4189

DOI: 10.1038/emboj.2012.159